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1,4-dihydro-3H-2-benzopyran-3-one → (E)-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzyl alcohol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,4-dihydro-3H-2-benzopyran-3-one | HCID 78092 | — |
| 反応物 | (E)-3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]benzeneamine | HCID 15136086 | — |
| 生成物 | (E)-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzyl alcohol | HCID 44211474 | — |
反応手順
A solution of 0.256 g of (E)-3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]benzeneamine and 0.148 g of 3-isochromanone was heated in a 126° C. oil bath for 17 hr. The residual materials were purified by silica gel chromatography using ethyl acetate-hexane (1:4 v/v) as the eluant to yield (E)-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzyl alcohol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05273986 |
| 出典データセット | uspto-grants-1993_12 |
| ORD ID | ord-04fb8bf6b4874d93888133f48f088bec |
| 出典メモ | uspto-grants-1993_12 |