HCID 15136077、化合物 → HCID 20084322、化合物

HRID 327554ノート

反応式

HRID 327554 の反応式
[CH:1]1([C:8]([CH2:10]Br)=O)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[N+:12]([C:15]1[CH:16]=[C:17](/[CH:21]=[CH:22]/[C:23](=[S:25])[NH2:24])[CH:18]=[CH:19][CH:20]=1)([O-:14])=[O:13]>C(O)C>[CH:1]1([C:8]2[N:24]=[C:23](/[CH:22]=[CH:21]/[C:17]3[CH:18]=[CH:19][CH:20]=[C:15]([N+:12]([O-:14])=[O:13])[CH:16]=3)[S:25][CH:10]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 15136077HCID 15136077、化合物HCID 218423502-Bromo-1-cycloheptylethan-1-one

生成物 1

HCID 20084322HCID 20084322、化合物収率 62.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution composed of 6.57 g of bromomethyl cycloheptyl ketone, 6.24 g of (E)-3-(3-nitrophenyl)-2-propenethioamide and 100 ml of ethyl alcohol was heated to reflux for 16 hr afterwhich it was diluted with 200 ml of ice water and extracted with methylene chloride. The combined extracts were washed with saturated sodium bicarbonate, brine, dried (MgSO4) and condensed in vacuo to yield 6.17 g of (E)-4-cycloheptyl-2-[2-(3-nitrophenyl)ethenyl]thiazole; m.p. 60° C. after crystallization from ethyl ether/hexane.

後処理

  1. temperaturewas heated
  2. temperatureto reflux for 16 hr afterwhich it
  3. extractionextracted with methylene chloride
  4. washThe combined extracts were washed with saturated sodium bicarbonate, brine
  5. customdried
  6. custom(MgSO4) and condensed in vacuo

出典と根拠

ORDレコード
ord-10a0b75634654b98bbba5d3a2d06a974
出典データセット
uspto-grants-1993_12
特許番号
US05273986

反応ノート

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