化工社化工社 化学情報印刷レポート · 研究参考用
Tetrahydropyran → (E)-2-[2-[3-[2-[4-(ethoxycarbonyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydropyran | HCID 8894 | — |
| 反応物 | Homophthalic anhydride | HCID 12801 | — |
| 反応物 | (E)-2-[2-(3-aminophenyl)ethenyl]-4-thiazolecarboxylic acid ethyl ester | HCID 14051204 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | (E)-2-[2-[3-[2-[4-(ethoxycarbonyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid | HCID 20084377 | 100.6% |
反応手順
A solution of 0.5 g of (E)-2-[2-(3-aminophenyl)ethenyl]-4-thiazolecarboxylic acid ethyl ester, 0.3 g of homophthalic anhydride, 15 ml of toluene and 5 ml of tetrahydropyran was heated to reflux for 0.5 hr. Upon cooling, a solid formed which was filtered to yield 0.8 g of (E)-2-[2-[3-[2-[4-(ethoxycarbonyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid; m.p. 221°-223° C. from ethanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05273986 |
| 出典データセット | uspto-grants-1993_12 |
| ORD ID | ord-287b1a368abe4273a1e9b79c8ed2fcfd |
| 出典メモ | uspto-grants-1993_12 |