Ethyl bromopyruvate → Ethyl 2-cyclobutylthiazole-4-carboxylate

HRID 327568ノート

反応式

HRID 327568 の反応式
[CH:1]1([C:5](=[S:7])[NH2:6])[CH2:4][CH2:3][CH2:2]1.Br[CH2:9][C:10](=O)[C:11]([O:13][CH2:14][CH3:15])=[O:12].C(=O)(O)[O-].[Na+]>C(O)C>[CH2:14]([O:13][C:11]([C:10]1[N:6]=[C:5]([CH:1]2[CH2:4][CH2:3][CH2:2]2)[S:7][CH:9]=1)=[O:12])[CH3:15]

参加物

5

反応物 3

HCID 66144Ethyl bromopyruvateHCID 516892Sodium BicarbonateHCID 22141088Cyclobutanecarbothioamide

生成物 1

HCID 54513950Ethyl 2-cyclobutylthiazole-4-carboxylate収率 39.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture composed of 9.7 g of cyclobutancarbothioamide, 16.5 g of ethyl bromopyruvate and 200 ml of ethyl alcohol was heated to reflux for 1 hr. The reaction mixture was partially condensed in vacuo and the residual materials were diluted with ice water and and excess of saturated sodium bicarbonate solution. The solids were collected to yield 7.0 g of 2-cyclobutyl-4-thiazolecarboxylic acid ethyl ester; m.p. 48°-50° C. after recrystallization from pentane.

後処理

  1. temperaturewas heated
  2. temperatureto reflux for 1 hr
  3. customcondensed in vacuo
  4. customThe solids were collected

出典と根拠

ORDレコード
ord-eddc81781e2944a5b902e1cac4c9313a
出典データセット
uspto-grants-1993_12
特許番号
US05273986

反応ノート

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