Tris(hydroxymethyl)aminomethane → (E)-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid tris-(hydroxymethyl)-amino-methane salt

HRID 327580

反応式

HRID 327580 の反応式
[CH:1]1([C:5]2[N:6]=[C:7](/[CH:10]=[CH:11]/[C:12]3[CH:13]=[C:14]([NH:18][C:19](=[O:30])[CH2:20][C:21]4[CH:29]=[CH:28][CH:27]=[CH:26][C:22]=4[C:23]([OH:25])=[O:24])[CH:15]=[CH:16][CH:17]=3)[S:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[OH:31][CH2:32][C:33]([CH2:37][OH:38])([CH2:35][OH:36])[NH2:34]>C(O)C>[OH:31][CH2:32][C:33]([CH2:37][OH:38])([CH2:35][OH:36])[NH2:34].[CH:1]1([C:5]2[N:6]=[C:7](/[CH:10]=[CH:11]/[C:12]3[CH:13]=[C:14]([NH:18][C:19](=[O:30])[CH2:20][C:21]4[CH:29]=[CH:28][CH:27]=[CH:26][C:22]=4[C:23]([OH:25])=[O:24])[CH:15]=[CH:16][CH:17]=3)[S:8][CH:9]=2)[CH2:2][CH2:3][CH2:4]1

参加物

4

反応物 2

HCID 6503Tris(hydroxymethyl)aminomethaneHCID 20084337(E)-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid

生成物 1

HCID 67807895(E)-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid tris-(hydroxymethyl)-amino-methane salt

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 0.418 g of (E)-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid and 0.1214 g of tris-(hydroxymethyl)-amino-methane were solubilized in 10 ml of ethyl alcohol with warming on a steam bath until all the solids had solubilized. After cooling the reaction mixture was condensed in vacuo at 40° C. to constant weight to yield (E)-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid tris-(hydroxymethyl)-amino-methane salt as a white solid.

後処理

  1. temperaturewith warming on a steam bath until all the solids
  2. temperatureAfter cooling the reaction mixture
  3. customcondensed in vacuo at 40° C. to constant weight

出典と根拠

ORDレコード
ord-95ccb0ee5527426282d02c9dc2f3e94e
出典データセット
uspto-grants-1993_12
特許番号
US05273986

関連ノート

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