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2-Naphthoxyacetic acid → 1,2,3,4-tetrahydro-5-methoxy-N-[2-(2-naphthalenyloxy)ethyl]-N-propyl-2-naphthalenamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Naphthoxyacetic acid | HCID 8422 | — |
| 反応物 | Phenoxyacetic Acid | HCID 19188 | — |
| 反応物 | 2-Propylamino-5-methoxytetralin | HCID 10242548 | — |
| 生成物 | 1,2,3,4-tetrahydro-5-methoxy-N-[2-(2-naphthalenyloxy)ethyl]-N-propyl-2-naphthalenamine | HCID 19926568 | — |
反応手順
In Example 29, phenoxyacetic acid was replaced with (2-naphthoxy)acetic acid and (-)-2-(N-n-propylamino)-5-methoxytetralin was replaced with (±)-2-(N-n-propylamino)-5-methoxytetralin. The resulting oil was subjected to flash chromatography (Silica: 8:2 pet ether/EtOAc) and the product showed characteristic peaks at: NMR (300 MHz, CDCl3) δ 7.8-6.6(m, 10H), 4.15(t, 2H), 3.8(S, 3H), 0.9(t, 3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05274003 |
| 出典データセット | uspto-grants-1993_12 |
| ORD ID | ord-ede8cac636874c9fad7af3f0d22ad6c7 |
| 出典メモ | uspto-grants-1993_12 |