化工社化工社 化学情報印刷レポート · 研究参考用
Phenoxyacetic Acid → (+)-1,2,3,4-tetrahydro-5-methoxy-N-[-2[(2,5-dimethyl)phenoxy]ethyl]-N-propyl-2-naphthalenamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenoxyacetic Acid | HCID 19188 | — |
| 反応物 | 2,5-Xylyloxyacetic acid | HCID 81817 | — |
| 反応物 | 2-Propylamino-5-methoxytetralin | HCID 10242548 | — |
| 生成物 | (+)-1,2,3,4-tetrahydro-5-methoxy-N-[-2[(2,5-dimethyl)phenoxy]ethyl]-N-propyl-2-naphthalenamine | HCID 19926555 | — |
反応手順
In Example 29, phenoxyacetic acid was replaced by 2,5-dimethylphenoxyacetic acid and (-)-2-(N-n-propylamino)-5-methoxytetralin was replaced by (+)-2-(N-n-propylamino)-5-methoxytetralin. The crude mixture was subjected to flash chromatography (Silica: 9:1 pet ether/EtOAc) and the product showed characteristic peaks at: NMR (300 MHz, CDCl3) δ 7.1-6.6(m, 6H), 4.0(t, 2H), 3.8(s, 3H), 2.3(s, 3H), 2.15(s, 3H), 0.9(t,3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05274003 |
| 出典データセット | uspto-grants-1993_12 |
| ORD ID | ord-1c93cd1dd537403aa99da155120c6798 |
| 出典メモ | uspto-grants-1993_12 |