Iodine → 6-Phenyl-2-pyridin-2-ylmethyl-isothiazolo[5,4-d]pyrimidin-3-one
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][NH:8][C:9]([C:11]1[C:12]([SH:23])=[N:13][C:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[N:15][CH:16]=1)=[O:10].II>>[C:17]1([C:14]2[N:13]=[C:12]3[S:23][N:8]([CH2:7][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=4)[C:9](=[O:10])[C:11]3=[CH:16][N:15]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1参加物
3
実験手順
Using the procedure of Example 20, 2.0 g (6.20 mmol) of 4-mercapto-2-phenyl-pyrimidine-5-carboxylic acid (pyridin-2-ylmethyl)-amide were treated with 1.73 g (6.82 mmol) of iodine to give 1.62 g of the title compound after recrystallization from isopropanol, mp 154°-156° C.
出典と根拠
- ORDレコード
- ord-9ccc055e75654930ad54bd09e669b039
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05733921
反応ノート
読み込み中…