Hydrochloric Acid → 3-amino-4-methyl-pentan-2-one
反応式
C([NH:4][CH:5]([CH:9]([CH3:11])[CH3:10])[C:6](=[O:8])[CH3:7])(=O)C.[ClH:12]>C(O)C>[ClH:12].[O:8]=[C:6]([CH:5]([NH2:4])[CH:9]([CH3:11])[CH3:10])[CH3:7]参加物
4
実験手順
A mixture of N-acetyl-2-keto-3-amino-4-methylpentane (6.33 g, 40.3 mmol) and 6M hydrochloric acid (65 ml) was heated at reflux overnight. The reaction mixture was cooled to room temperature, ethanol (100 ml) was added and the mixture concentrated under reduced pressure. The mixture was triturated with ether to give a precipitate which was collected by filtration. Crystallisation from acetone gave 2-keto-3-amino-4-methylpentane hydrochloride (2.9 g, 63%) as a white crystalline solid.
後処理
- temperaturewas heated
- temperatureat reflux overnight
- concentrationthe mixture concentrated under reduced pressure
- customThe mixture was triturated with ether
- customto give a precipitate which
- filtrationwas collected by filtration
- customCrystallisation from acetone
出典と根拠
- ORDレコード
- ord-cedb8de6facd4d2cb277e55f0f74b1f2
- 出典データセット
- uspto-grants-1993_12
- 特許番号
- US05274094
反応ノート
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