Benzoyl chloride → 4-Methoxybenzophenone

HRID 327852

反応式

HRID 327852 の反応式
[C:1]1([O:7][CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:9](Cl)(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[Cl-].[Al+3].[Cl-].[Cl-]>CCCCCC>[CH3:8][O:7][C:1]1[CH:6]=[CH:5][C:4]([C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:16])=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 7412Benzoyl chlorideHCID 7519AnisoleHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 691464-Methoxybenzophenone

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

Anisole (0.1 mole, 10.8 grams) and benzoyl chloride (0.1 mole, 14 grams) were dissolved in 200 milliliters of hexane and stirred at room temperature while 15 grams of anhydrous aluminum chloride were added slowly over a period of 15 minutes. The reaction mixture was stirred an additional 15 minutes and then the hexane decanted. The resulting viscous residue in the reaction flask was carefully hydrolyzed with 200 milliliters of a mixture of ice and dilute hydrochloric acid. The resulting organic fraction was taken up in dichloromethane and the resulting solution washed with water. Dichloromethane solvent was removed on a rotary evaporator leaving an oil product that solidified on standing. The solidified product was broken-up, washed with two 50 milliliters portions of pentane, and suction dried yielding 4-methoxybenzophenone.

後処理

  1. additionwere added slowly over a period of 15 minutes
  2. customthe hexane decanted
  3. washthe resulting solution washed with water
  4. customDichloromethane solvent was removed on a rotary evaporator
  5. customleaving an oil product that
  6. washwashed with two 50 milliliters portions of pentane, and suction
  7. customdried

出典と根拠

ORDレコード
ord-01ef589c464545b7a41f11665b6a44da
出典データセット
uspto-grants-1993_12
特許番号
US05274132

関連ノート

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