Ammonium Hydroxide → 1-(2-Amino-1,3-thiazol-4-yl)ethan-1-one

HRID 32804ノート

反応式

HRID 32804 の反応式
Cl.[NH2:2][C:3]1[S:4][CH:5]=[C:6]([C:8](=[O:10])[CH3:9])[N:7]=1.[OH-].[NH4+]>O>[NH2:2][C:3]1[S:4][CH:5]=[C:6]([C:8](=[O:10])[CH3:9])[N:7]=1

参加物

4

反応物 2

HCID 14923Ammonium HydroxideHCID 50998257HCID 50998257、化合物

生成物 1

HCID 31119641-(2-Amino-1,3-thiazol-4-yl)ethan-1-one収率 62.8%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

1-(2-Amino-thiazol-4-yl)-ethanone hydrochloride (5.6 g 29.1 mmol) was dissolved in water (15 mL) and cooled in an ice bath. To this was added dropwise 17 N ammonium hydroxide (15 mL, 105 mmol). The resulting mixture was stirred for 15 minutes than filtered and washed with cold water (3×), cold methanol (3×50 mL), ethyl ether (3×10 mL). The precipitate was dried first by passing air through the material and then in vacuo to give 1-(2-amino-thiazol-4-yl)-ethanone as a pale yellow solid (2.6 g, 57%).

後処理

  1. temperaturecooled in an ice bath
  2. filtrationthan filtered
  3. washwashed with cold water (3×), cold methanol (3×50 mL), ethyl ether (3×10 mL)
  4. customThe precipitate was dried first

出典と根拠

ORDレコード
ord-20db3dd31de543458c8215a5f7af857c
出典データセット
uspto-grants-2008_09
特許番号
US07427635B2

反応ノート

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