Acetic Acid → Methyl 2-(4-hydroxyphenyl)propanoate

HRID 328167

反応式

HRID 328167 の反応式
[C:1](O)(=O)C.CO.[P].C[O:9][C:10]1[CH:15]=[CH:14][C:13]([CH:16]([CH3:20])[C:17]([OH:19])=[O:18])=[CH:12][CH:11]=1>I>[OH:9][C:10]1[CH:15]=[CH:14][C:13]([CH:16]([CH3:20])[C:17]([O:19][CH3:1])=[O:18])=[CH:12][CH:11]=1

参加物

6

反応物 4

HCID 176Acetic AcidHCID 887MethanolHCID 257576p-Methoxyphenylpropionic acidHCID 5462309Phosphorus

生成物 1

HCID 12549710Methyl 2-(4-hydroxyphenyl)propanoate

試薬・触媒・溶媒 1

HCID 24841Hydrogen iodide溶媒

実験手順

In a mixture of 12ml of hydroiodic acid, 90ml of acetic acid and 1g of phosphorus 10g of 2-(4-methoxyphenyl)propionic acid was refluxed for 3 hours and the reaction mixture was concentrated. 20ml of methanol and 2ml of sulfuric acid were added to the residue and the mixture was refluxed for one hour. After the methanol was concentrated, the water was added to the residue and extracted with ether. The extract was washed over magnesium sulfate and the ether was distilled off. The residue was distilled under reduced pressure to give the object compound having b.p. 150° - 153° C/6mm Hg in a yield of 6.7g (67%)

後処理

  1. temperaturewas refluxed for 3 hours
  2. concentrationthe reaction mixture was concentrated
  3. addition20ml of methanol and 2ml of sulfuric acid were added to the residue
  4. temperaturethe mixture was refluxed for one hour
  5. concentrationAfter the methanol was concentrated
  6. additionthe water was added to the residue
  7. extractionextracted with ether
  8. washThe extract was washed over magnesium sulfate
  9. distillationthe ether was distilled off
  10. distillationThe residue was distilled under reduced pressure
  11. customto give the object compound

出典と根拠

ORDレコード
ord-bae7d0942c714db0bf3630cafccbeb6d
出典データセット
uspto-grants-1977_04
特許番号
US04016193

関連ノート

読み込み中…