2,4-Dinitrophenol → 1-Methoxy-3-methyl-1-[(3-methylbut-2-en-1-yl)oxy]but-2-ene

In a 50 ml. one-neck flask was placed 5.5 g. (0.0422 mol.) of 1,1-dimethoxy-3-methyl-2-butene and 10.0 g. (0.116 mol.) of prenol and 0.40 g. (0.002 mol.) of 2,4-dinitrophenol. The resulting solution was degassed with nitrogen and sealed with a serum cap and stirred at room temperature for 76 hours. The reaction solution was then diluted with 100 ml. of hexane and washed with 3 × 100 ml. of 1.0 N aqueous NaOH solution and 2 × 100 ml. of saturated aqueous NaCl solution. The combined water washings were back with extracted 1 × 50 ml. of hexane. The combined hexane solutions were dried (Na2SO4) and concentrated to give 9.0 g. of crude product. Distillation of 8.3 g. at 20 mmHg and a bath temperature of 55°-60° gave 1.48 g. of prenol. Continued distillation initially at 0.20 mmHg gave 2.43 g. of 1-methoxy-1-(3-methylbut-2-enoxy)-3-methyl-2-butene (b.p. 40°-45° at 0.20 mmHg) and finally at 0.050 mmHg gave 3.29 g. of 1,1-bis-(3-methylbut-2-enoxy)-3-methylbut-2-ene (b.p. 70°-75° at 0.050 mmHg).

1. customone-neck flask was placed
2. customThe resulting solution was degassed with nitrogen
3. customsealed with a serum
4. customcap
5. additionThe reaction solution was then diluted with 100 ml
6. washof hexane and washed with 3 × 100 ml
7. extractionwith extracted 1 × 50 ml
8. dry with materialThe combined hexane solutions were dried (Na2SO4)
9. concentrationconcentrated
10. customto give 9.0 g
11. distillationDistillation of 8.3 g
12. customat 20 mmHg and a bath temperature of 55°-60° gave 1.48 g
13. distillationContinued distillation initially at 0.20 mmHg
14. customgave 2.43 g

ORDレコード

ord-2000c1b4b6b3455ea2baa7f0f2edf802

出典データセット

uspto-grants-1977_04

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04016212