Phosgene → 2-Ethylbutyl carbonochloridate

HRID 328343

反応式

HRID 328343 の反応式
[CH2:1]([CH:3]([CH2:6][CH3:7])[CH2:4][OH:5])[CH3:2].[C:8](Cl)([Cl:10])=[O:9].ClC([O-])=O>C1C=CC=CC=1>[Cl:10][C:8]([O:5][CH2:4][CH:3]([CH2:6][CH3:7])[CH2:1][CH3:2])=[O:9]

参加物

5

反応物 3

HCID 6371PhosgeneHCID 73582-Ethyl-1-butanolHCID 21226386Carbonochloridate

生成物 1

HCID 544120422-Ethylbutyl carbonochloridate

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

20.4 G. (0.2 moles) of 2-ethyl-1-butanol is added dropwise under anhydrous conditions to 250 ml. (0.4 moles) of 17.2% phosgene solution in benzene with stirring in an ice bath. The addition is complete in 70 minutes and the solution is allowed to gradually warm to room temperature and stirred for 16 hours. The excess phosgene and hydrogen chloride are removed with a stream of nitrogen and the residual solution evaporated to dryness in vacuo affording 17.9 g. (54%) of a light yellow oil which IR demonstrates having a strong chloroformate band and no hydroxy. The oil is used as is in further reactions.

後処理

  1. additionThe addition
  2. customThe excess phosgene and hydrogen chloride are removed with a stream of nitrogen
  3. customthe residual solution evaporated to dryness in vacuo
  4. customaffording 17.9 g

出典と根拠

ORDレコード
ord-efbfbebf66014f23bbf37360e380f506
出典データセット
uspto-grants-1977_04
特許番号
US04017505

関連ノート

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