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4-Bromophenacyl bromide → p-Bromophenacyl 6-hydroxycaproate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Bromophenacyl bromide | HCID 7454 | — |
| 反応物 | Dicyclohexano-18-crown-6 | HCID 85955 | — |
| 反応物 | 21810-34-4 | HCID 23712826 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | p-Bromophenacyl 6-hydroxycaproate | HCID 13272687 | — |
反応手順
A mixture of 8.5 g. (50 mmoles) of potassium 6-hydroxycaproate, 13.9 g. (50 mmoles) of p-bromophenacyl bromide, 0.75 g. (2 mmoles) of dicyclohexyl-18 -crown-6 in 500 ml. of acetonitrile is refluxed with stirring for 1 hour and stirred at room temperature overnight. The mixture is filtered and the filtrate evaporated to dryness in vacuo. The residual solid is recrystallized from benzene-hexane mixture affording 14.1 g. of p-bromophenacyl 6-hydroxycarproate, m.p. 79°-81° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04017504 |
| 出典データセット | uspto-grants-1977_04 |
| ORD ID | ord-a734423e92bc44cb9dbd3621076924e4 |
| 出典メモ | uspto-grants-1977_04 |