HCID 12353591、化合物 → Trepibutone

HRID 328371

反応式

HRID 328371 の反応式
[CH2:1]([O:3][C:4]1[CH:16]=[C:15]([O:17][CH2:18][CH3:19])[C:14]([O:20][CH2:21][CH3:22])=[CH:13][C:5]=1[C:6](/[CH:8]=[CH:9]/[C:10]([OH:12])=[O:11])=[O:7])[CH3:2]>[Pd].CO>[CH2:1]([O:3][C:4]1[CH:16]=[C:15]([O:17][CH2:18][CH3:19])[C:14]([O:20][CH2:21][CH3:22])=[CH:13][C:5]=1[C:6]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[O:7])[CH3:2]

参加物

4

反応物 1

HCID 12353591HCID 12353591、化合物

生成物 1

HCID 5536Trepibutone

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 1.0 part by weight of 3-(2',4',5'-triethoxybenzoyl)-trans-acrylic acid, 50 parts by volume of methanol and 0.2 part by weight of 5% palladium-charcoal is subjected to catalytic reduction at 25° C under atmospheric pressure for 1 hour. After removal of the catalyst by filtration, the filtrate is evaporated and the residue is recrystallized from aqueous ethanol to give 0.85 part by weight of 3-(2',4',5'-triethoxybenzoyl)-propionic acid as pale yellow needles melting at 150°-151° C.

後処理

  1. customAfter removal of the catalyst
  2. filtrationby filtration
  3. customthe filtrate is evaporated
  4. customthe residue is recrystallized from aqueous ethanol

出典と根拠

ORDレコード
ord-04f8794cb62d44c7aa771fa08e98e8bb
出典データセット
uspto-grants-1977_04
特許番号
US04017517

関連ノート

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