Ethyl pyruvate → 7-chloro-2-[[1-(ethoxycarbonyl)ethylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine

HRID 328382

反応式

HRID 328382 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][NH2:13])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:6]=2[CH:20]=1.[C:21]([O:26][CH2:27][CH3:28])(=[O:25])[C:22]([CH3:24])=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:22]([C:21]([O:26][CH2:27][CH3:28])=[O:25])[CH3:24])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:6]=2[CH:20]=1

参加物

3

反応物 2

HCID 12041Ethyl pyruvateHCID 123908747-Chloro-2-hydrazinyl-5-phenyl-3H-1,4-benzodiazepine

生成物 1

HCID 536573497-chloro-2-[[1-(ethoxycarbonyl)ethylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine

実験手順

In the same manner given in Example 1, 7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine and ethyl pyruvate gives 7-chloro-2-[[1-(ethoxycarbonyl)ethylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine as an oily product. NMR (CDCl3) δ1.20 (t, 3, CH2CH3), 2.25 (2, 3, CH3), 4.23 (q. 2, CH2CH3), 4.50 (broad s, 2, 3-CH2), between 6.95 and 7.6 (m, 9, NH and arom H's).

出典と根拠

ORDレコード
ord-73f436df3b03411f9c51c5a1a890dffd
出典データセット
uspto-grants-1977_04
特許番号
US04017492

関連ノート

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