Diazomethane → 7-chloro-2-[[1-(methoxycarbonyl)-3-butenylidene]hydrazino]-5-(o-chlorphenyl)-3H-1,4-benzodiazepine

反応式

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:14]([C:18]([OH:20])=[O:19])[CH2:15][CH:16]=[CH2:17])[CH2:9][N:8]=[C:7]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[Cl:27])[C:6]=2[CH:28]=1.[N+](=[CH2:31])=[N-]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:14]([C:18]([O:20][CH3:31])=[O:19])[CH2:15][CH:16]=[CH2:17])[CH2:9][N:8]=[C:7]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[Cl:27])[C:6]=2[CH:28]=1

参加物

反応物 2

HCID 9550Diazomethane

HCID 867346417-chloro-2-[(1-carboxy-3-butenylidene)hydrazino]-5-(o-chlorophenyl)-3H-1,4-benzodiazepine

生成物 1

HCID 737934997-chloro-2-[[1-(methoxycarbonyl)-3-butenylidene]hydrazino]-5-(o-chlorphenyl)-3H-1,4-benzodiazepine

実験手順

In the manner given in Example 10, a solution of 7-chloro-2-[(1-carboxy-3-butenylidene)hydrazino]-5-(o-chlorophenyl)-3H-1,4-benzodiazepine can be treated with ethereal diazomethane to give 7-chloro-2-[[1-(methoxycarbonyl)-3-butenylidene]hydrazino]-5-(o-chlorphenyl)-3H-1,4-benzodiazepine.

出典と根拠

ORDレコード: ord-806eaa5412dc43d48cd651dbc83cfd1d
出典データセット: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04017492

反応ノート

読み込み中…