7-Chloro-5-(2-chlorophenyl)-2-hydrazinyl-3H-1,4-benzodiazepine → 7-chloro-2-[[1-carboxy-3-(dimethylamino)propylidene]hydrazino]-5-(o-chlorophenyl)-3H-1,4-benzodiazepine

HRID 328421ノート

反応式

HRID 328421 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][NH2:13])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[Cl:20])[C:6]=2[CH:21]=1.[CH3:22][N:23]([CH3:31])[CH2:24][CH2:25][C:26](=O)[C:27]([OH:29])=[O:28]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:26]([C:27]([OH:29])=[O:28])[CH2:25][CH2:24][N:23]([CH3:31])[CH3:22])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[Cl:20])[C:6]=2[CH:21]=1

参加物

3

反応物 2

HCID 123908757-Chloro-5-(2-chlorophenyl)-2-hydrazinyl-3H-1,4-benzodiazepineHCID 214415744-(Dimethylamino)-2-oxobutanoic acid

生成物 1

HCID 540586677-chloro-2-[[1-carboxy-3-(dimethylamino)propylidene]hydrazino]-5-(o-chlorophenyl)-3H-1,4-benzodiazepine

実験手順

In the manner given in Example 13, 7-chloro-2-hydrazino-5-(o-chlorophenyl)-3H-1,4-benzodiazepine can be stirred with 4-(dimethylamino)-2-oxobutanoic acid at room temperature to give 7-chloro-2-[[1-carboxy-3-(dimethylamino)propylidene]hydrazino]-5-(o-chlorophenyl)-3H-1,4-benzodiazepine.

出典と根拠

ORDレコード
ord-f9ae089abdfb40eab2dbbd7d7a2d3a2e
出典データセット
uspto-grants-1977_04
特許番号
US04017492

反応ノート

読み込み中…