Diketene → N-(2-Methylpropanoyl)-3-oxobutanamide

HRID 328677ノート

反応式

HRID 328677 の反応式
[C:1]([NH2:6])(=[O:5])[CH:2]([CH3:4])[CH3:3].[CH2:7]=[C:8]1[O:12][C:10](=[O:11])[CH2:9]1>>[C:10]([NH:6][C:1](=[O:5])[CH:2]([CH3:4])[CH3:3])(=[O:11])[CH2:9][C:8]([CH3:7])=[O:12]

参加物

3

反応物 2

HCID 12661DiketeneHCID 68424Isobutyramide

生成物 1

HCID 12682092N-(2-Methylpropanoyl)-3-oxobutanamide収率 38.7%

実験手順

A 250 ml, three-necked, round bottom flask, was equipped with a condenser, drying tube, mechanical stirrer, gas inlet tube, thermometer and heating mantle. Toluene (100 ml) was introduced and hydrogen chloride gas was bubbled through the solvent until the solution was saturated. Isobutyramide (8.70 g, 0.10 mole) was added and the mixture was heated to 92°. Diketene (8.40 g, 0.10 mole) was added over a 6 minute period and after heating for 15 minutes, a 38.7% yield of N-acetoacetylisobutyramide was obtained.

後処理

  1. customA 250 ml, three-necked, round bottom flask, was equipped with a condenser
  2. customdrying tube, mechanical stirrer, gas inlet tube
  3. temperaturethermometer and heating mantle
  4. additionToluene (100 ml) was introduced
  5. customhydrogen chloride gas was bubbled through the solvent until the solution
  6. temperaturethe mixture was heated to 92°
  7. temperatureafter heating for 15 minutes

出典と根拠

ORDレコード
ord-d58c3049331d42269842d30240302ecd
出典データセット
uspto-grants-1977_04
特許番号
US04018771

反応ノート

読み込み中…