Acetic Anhydride → N-piperidin-1-ium-4-ylacetamide acetate

HRID 32878

反応式

HRID 32878 の反応式
[NH2:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[C:8]([O:11][C:12](=[O:14])[CH3:13])(=[O:10])[CH3:9]>C(OCC)C>[C:8]([O-:11])(=[O:10])[CH3:9].[C:12]([NH:1][CH:2]1[CH2:7][CH2:6][NH2+:5][CH2:4][CH2:3]1)(=[O:14])[CH3:13]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 4243614-Piperidinamine

生成物 1

HCID 11171677N-piperidin-1-ium-4-ylacetamide acetate収率 714.5%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

To a solution of 4-aminopiperidine (524 μL, 5.00 mmol) in diethyl ether (20 mL) was added a solution of acetic anhydride (567 μL, 0.600 mmol)) in diethyl ether (20 mL) over 10 minutes and the resulting mixture was stirred for 1 h at RT. The solid was collected on a Buchner funnel, washed with diethyl ether (50 mL), and dried under vacuo to give 867 mg (86%) of the title compound as a white solid. 1H-NMR (400 MHz, CDCl3): δ 7.82 (d, 1H, J=10.5 Hz), 4.20-4.16 (m, 1H), 3.78-3.71 (m, 2H), 3.45 (br s, 1H), 3.09 (m, 1H), 2.69 (m, 1H), 1.98 (s, 3H), 1.79 (s, 3H), 1.78-1.69 (m, 2H), 1.28-1.13 (m, 2H).

後処理

  1. customThe solid was collected on a Buchner funnel
  2. washwashed with diethyl ether (50 mL)
  3. customdried under vacuo

出典と根拠

ORDレコード
ord-a1d62dee5c5640d8ab6435b7339a73bc
出典データセット
uspto-grants-2008_09
特許番号
US07427683B2

関連ノート

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