化工社化工社 化学情報印刷レポート · 研究参考用
1-Naphthol → Propranolol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Naphthol | HCID 7005 | — |
| 反応物 | 1-(Propan-2-yl)azetidin-3-ol | HCID 544677 | — |
| 生成物 | Propranolol | HCID 4946 | — |
反応手順
1-(isopropyl)-3-azetidinol and α-naphthol were reacted in the same manner as in Example 6 to form 1-(α-naphthoxy)-3-(iso-propylamino)-2-propanol. Then the propanol was dissolved in anhydrous ether and was converted to a hydrochloride by blowing a hydrochloric acid gas into the resulting solution. As a result 1-(α-naphthoxy)-3-(isopropylamino)-2-propanol hydrochloride melting at 162°-164° C was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04018824 |
| 出典データセット | uspto-grants-1977_04 |
| ORD ID | ord-cc1887e3dcee4e6ab9cac14005c5667c |
| 出典メモ | uspto-grants-1977_04 |