関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 1-(Propan-2-yl)azetidin-3-ol | HCID 544677 | — |
| 反応物 | 1-Phenoxyphenol | HCID 20517352 | — |
| 生成物 | 1-(p-Phenoxyphenoxy)-3-(iso-propylamino)-2-propanol | HCID 20517315 | 58% |
反応手順
To a mixture of 5.8 parts of 1-(iso-propyl)-3-azetidinol and 9.3 parts of 1-phenoxyphenol 0.1 part of sodium hydroxide was added, and the mixture was heated under nitrogen gas at 160° C. for 18 hours. The reaction mixture was cooled and extracted with ether. The extract was washed in water and then the solvent was distilled off. Recrystallization of the residue gave 16.1 parts of 1-(p-phenoxyphenoxy)-3-(iso-propylamino)-2-propanol having a melting point of 72°-74° C. The yield was 58%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04018824 |
|---|
| 出典データセット | uspto-grants-1977_04 |
|---|
| ORD ID | ord-439dc4399852448982e7db8374c60e24 |
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| 出典メモ | uspto-grants-1977_04 |
|---|
