関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 1-(Propan-2-yl)azetidin-3-ol | HCID 544677 | — |
| 反応物 | 6-methoxy-1-naphthol | HCID 11008416 | — |
| 生成物 | 1-(6'-Methoxy-1-naphthoxy)-3-(iso-propylamino)-2-propanol hydrochloride | HCID 20517328 | 57.5% |
反応手順
A mixture of 9.5 parts of 6-methoxy-1-naphthol, 5.8 parts of 1-(iso-propyl)-3-azetidinol and 0.3 part of potassium hydroxide was heated under nitrogen gas at 140° C. for 8 hours with agitation. The reaction mixture was treated in the same manner as in Example 1, and when the resulting hydrochloride was recrystallized from iso-propyl alcohol, there was obtained 17.7 parts of 1-(6'-methoxy-1-naphthoxy)-3-(iso-propylamino)-2-propanol hydrochloride melting at 165° - 167° C. The yield was 57.5%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04018824 |
|---|
| 出典データセット | uspto-grants-1977_04 |
|---|
| ORD ID | ord-d56827fc3bf84ff481daf1a4e2331829 |
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| 出典メモ | uspto-grants-1977_04 |
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