Diisopropylethylamine → HCID 11573636、化合物

関与物質

反応手順

Using a procedure similar to Example 3, step (d), 4-N,N-dimethyl-2-piperidin-1-yl-benzene-1,4-diamine (89 mg, 0.4 mmol, as prepared in the previous step) was allowed to react with 5-cyano-furan-2-carbonyl chloride (236 mg, 1.5 mmol) in the presence of DIEA (0.15 mL, 0.88 mmol) to afford 84.7 mg (63%) of the title compound as a yellow powder. 1H-NMR (CDCl3, 400 MHz): δ 9.50 (br s, 1H), 8.29 (d, 1H, J=8.9 Hz), 7.21-7.24 (m, 2H), 6.58 (d, 1H, J=2.7 Hz), 6.54 (dd, 1H, J=2.8, 9.0 Hz), 2.95 (s, 6H), 2.84-2.87 (m, 4H), 1.78-1.82 (m, 4H), 1.65 (br s, 2H); Mass spectrum (ESI, m/z): Calcd. for C19H22N4O2, 339.1 (M+H), found 339.1.

情報源と証拠