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10-(3-Chloropropyl)-2-(trifluoromethyl)-10H-phenothiazine → 2-Trifluoromethyl-10-[3-(4-[4-hydroxybutoxy]-piperidino)-propyl]-phenothiazine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 10-(3-Chloropropyl)-2-(trifluoromethyl)-10H-phenothiazine | HCID 74294 | — |
| 反応物 | 4-(4-Piperidyloxy)-butanol | HCID 21440902 | — |
| 生成物 | 2-Trifluoromethyl-10-[3-(4-[4-hydroxybutoxy]-piperidino)-propyl]-phenothiazine hydrochloride | HCID 21440928 | 39% |
反応手順
Using the procedure of Example XI, 49.7 g (0.145 mole) of 2-trifluoromethyl-10-(3-chloropropyl)-phenothiazine and 25.5 g (0.145 mole) of 4-(4-piperidyloxy)-butanol were reacted to obtain 29 g (39% yield) of 2-trifluoromethyl-10-[3-(4-[4-hydroxybutoxy]-piperidino)-propyl]-phenothiazine hydrochloride in the form of white crystals melting at 67° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04018922 |
| 出典データセット | uspto-grants-1977_04 |
| ORD ID | ord-c91d8cc0d323414aa71221798c7b4f3f |
| 出典メモ | uspto-grants-1977_04 |