Benzoyl isothiocyanate → N-benzoyl-N'-[2-(2-pyrimidylmethylthio)ethyl]thiourea

反応式

[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[N:11]=[CH:10][CH:9]=[CH:8][N:7]=1.[C:12]([N:20]=[C:21]=[S:22])(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:12]([NH:20][C:21]([NH:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[N:7]=[CH:8][CH:9]=[CH:10][N:11]=1)=[S:22])(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

反応物 2

HCID 68284Benzoyl isothiocyanate

HCID 202424852-[(2-Aminoethyl)thiomethyl]pyrimidine

生成物 1

HCID 20557794N-benzoyl-N'-[2-(2-pyrimidylmethylthio)ethyl]thiourea

実験手順

By the procedure of Example 18, 2-[(2-aminoethyl)-thiomethyl]pyrimidine is reacted with benzoyl isothiocyanate to give N-benzoyl-N'-[2-(2-pyrimidylmethylthio)ethyl]thiourea. Removing the benzoyl group by the procedure of Example 18 give N-[2-(2-pyrimidylmethlthio)ethyl]thiourea.

出典と根拠

ORDレコード: ord-da55414c5b324891bbb5fc3d35a388b3
出典データセット: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04018931

反応ノート

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