化工社化工社 化学情報印刷レポート · 研究参考用
Methylamine → N-methyl-(4-nitro-3-piperidin-1-yl-phenyl)-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methylamine | HCID 6329 | — |
| 反応物 | 1-(5-Fluoro-2-nitrophenyl)piperidine | HCID 53256708 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | N-methyl-(4-nitro-3-piperidin-1-yl-phenyl)-amine | HCID 68680582 | 100% |
反応手順
A solution of 1-(5-fluoro-2-nitro-phenyl)-piperidine (200 mg, 0.89 mmol, as prepared in Example 5, step (a)) in 4 mL of 2M methylamine in MeOH was heated in a sealed tube for 12 h at 80° C. solvent under vacuum afforded methyl-(4-nitro-3-piperidin-1-yl-phenyl)-amine (209 mg, 100%). Mass spectrum (ESI, m/z): Calcd. for C12H17N3O2, 236.1 (M+H), found 236.1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07427683B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-2bffe412714a4a838cabd1083a9c4c5c |
| 出典メモ | uspto-grants-2008_09 |