Ethylenediamine → N-Methyl-N'-[2-(2-thiazolylmethylamino)ethyl]urea

HRID 329112ノート

反応式

HRID 329112 の反応式
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH2:6][NH:7][CH2:8][CH2:9][NH2:10].C(N)CN.ClCC1SC=CN=1.[CH3:22][N:23]=[C:24]=[O:25]>>[CH3:22][NH:23][C:24]([NH:10][CH2:9][CH2:8][NH:7][CH2:6][C:2]1[S:1][CH:5]=[CH:4][N:3]=1)=[O:25]

参加物

5

反応物 4

HCID 3301EthylenediamineHCID 12228Methyl IsocyanateHCID 140908642-(Chloromethyl)-1,3-thiazoleHCID 17944882N-(2-thiazolylmethyl)ethylenediamine

生成物 1

HCID 20557949N-Methyl-N'-[2-(2-thiazolylmethylamino)ethyl]urea

実験手順

N-(2-Thiazolylmethyl)ethylenediamine, prepared by reacting ethylenediamine with 2-chloromethylthiazole by the procedure of Example 40, is reacted with methyl isocyanate by the procedure of Example 24 to give, after concentrating and separating by column chromatography, the title compound.

後処理

  1. customto give
  2. concentrationafter concentrating
  3. customseparating by column chromatography

出典と根拠

ORDレコード
ord-306d0135d0694b778acdfaa42317621d
出典データセット
uspto-grants-1977_04
特許番号
US04018931

反応ノート

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