2,6-Dimethylaniline → N-(2',6'-dimethylphenyl)-1-methoxymethylethylamine

HRID 329130ノート

反応式

HRID 329130 の反応式
[NH2:1][C:2]1[C:3]([CH3:9])=[CH:4][CH:5]=[CH:6][C:7]=1[CH3:8].[CH3:10][O:11][CH2:12][CH:13](OS(C1C=CC(C)=CC=1)(=O)=O)[CH3:14]>C1(C)C=CC=CC=1.CCOCC>[CH3:10][O:11][CH2:12][CH:13]([NH:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH3:9])[CH3:14]

参加物

5

反応物 2

HCID 68962,6-DimethylanilineHCID 1270077423946-74-9

生成物 1

HCID 10899497N-(2',6'-dimethylphenyl)-1-methoxymethylethylamine

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 3283Diethyl Ether溶媒

実験手順

Manufacture of the starting material: A solution of 484 g (4 mole) of 2,6-xylidine and 490 g (2 mole) of p-toluenesulphonic acid-(1-methoxyprop-2-yl)-ester in 1000 ml of toluene is refluxed for 25 hours. The reaction mixture is cooled, then made alkaline and diluted with ether. The organic phase is repeatedly washed with water and dried with magnesium sulphate. Evaporation of the solvent and subsequent distillation of the residue yields the desired N-(1-methoxyprop-2-yl)-2,6-xylidine with a boiling point of 70°-72° C/0.4 Torr.

後処理

  1. temperatureThe reaction mixture is cooled
  2. washThe organic phase is repeatedly washed with water
  3. dry with materialdried with magnesium sulphate
  4. customEvaporation of the solvent and subsequent distillation of the residue

出典と根拠

ORDレコード
ord-49f2dafd5f774e24ac04f87ecb57e8c3
出典データセット
uspto-grants-1977_04
特許番号
US04019894

反応ノート

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