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2,6-Dichlorobenzyl chloride → 2-(2,6-dichlorophenylmethylthio)pyridine N-oxide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,6-Dichlorobenzyl chloride | HCID 74832 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | HCID 178526253 | HCID 178526253 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-(2,6-dichlorophenylmethylthio)pyridine N-oxide | HCID 12431503 | 92% |
反応手順
A mixture of 37 gms (0.1 mole) 2-mercaptopyridine N-oxide, sodium salt (40% aqueous solution) and 19.5 gms (0.1 mole) 2,6-dichlorobenzylchloride in 200 ml of ethanol is warmed to 65° - 70° for thirty minutes, cooled and filtered. The filter cake is washed thoroughly with water and finally with 40 ml of acetone. The dry cake (25.3 gms) represents a 92% yield of 2-(2,6-dichlorophenylmethylthio)pyridine N-oxide. Melting point 240° - 241° C. Structure confirmed by IR and NMR.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04019893 |
| 出典データセット | uspto-grants-1977_04 |
| ORD ID | ord-3738219504b04e26821a1b48bc817ea8 |
| 出典メモ | uspto-grants-1977_04 |