Hydrochloric Acid → 5-(2-Amino-4,5-dimethoxyphenyl)-s-triazole

反応式

ClC1[N:11]2[CH:12]=[N:13][N:14]=[C:10]2[C:9]2[CH:8]=[C:7]([O:15][CH3:16])[C:6]([O:17][CH3:18])=[CH:5][C:4]=2[N:3]=1.[OH-].[K+].Cl>>[NH2:3][C:4]1[CH:5]=[C:6]([O:17][CH3:18])[C:7]([O:15][CH3:16])=[CH:8][C:9]=1[C:10]1[NH:14][N:13]=[CH:12][N:11]=1

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 14797Potassium Hydroxide

HCID 214051435-Chloro-8,9-dimethoxy-1,2,4-triazolo[4,3-c]quinazoline

生成物 1

HCID 214390785-(2-Amino-4,5-dimethoxyphenyl)-s-triazole

実験手順

To a flask containing 46 gms. of 5-chloro-8,9-dimethoxy-1,2,4,triazolo[4,3-c]quinazoline is added 1000 ml. of a 10% KOH solution and the resulting mixture heated to reflux. A gentle reflux is maintained overnight after which time the mixture is neutralized to pH 7.0 with cooling and stirring by adding dropwise a 1:1 HCl solution and the resulting precipitate filtered off. The aqueous layer is washed 3 or 4 times with ethyl acetate, dried and evaporated in vacuo to dryness. The residue is recrystallized from ethanol to obtain 5-(2-amino-4,5-dimethoxyphenyl)-s-triazole, m.p. 205°-210° C.