Ammonia → 3,5-Dichloro-2-hydroxybenzamide

HRID 329193ノート

反応式

HRID 329193 の反応式
[Cl:1][C:2]1[CH:11]=[C:10]([Cl:12])[CH:9]=[C:4]([C:5](OC)=[O:6])[C:3]=1[OH:13].[NH3:14]>>[Cl:1][C:2]1[CH:11]=[C:10]([Cl:12])[CH:9]=[C:4]([C:5]([NH2:14])=[O:6])[C:3]=1[OH:13]

参加物

3

反応物 2

HCID 222Ammonia2 回HCID 82082Benzoic acid, 3,5-dichloro-2-hydroxy-, methyl ester

生成物 1

HCID 125631993,5-Dichloro-2-hydroxybenzamide

反応条件

温度
25 °C

実験手順

A 1 liter Parr autoclave was charged with 221 g. (1 mole) -dichlorophenyl)- of methyl 3,5-dichlorosalicylate and 140 g. (8 moles) of anhydrous ammonia. The mixture was stirred at 25° C for 24 hours. After venting excess ammonia, the product was ground to a fine powder and triturated with boiling chloroform. The mixture was filtered while hot and the residue weighed 153 g. Analysis by infrared, gas chromatography, and nuclear magnetic resonance confirmed that the product was 3,5-dichlorosalicylamide.

後処理

  1. additionA 1 liter Parr autoclave was charged with 221 g
  2. customtriturated with boiling chloroform
  3. filtrationThe mixture was filtered while hot and the residue

出典と根拠

ORDレコード
ord-a66591768d304c25bc90ad70e522d405
出典データセット
uspto-grants-1977_04
特許番号
US04020081

反応ノート

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