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2-Bromo-3,3-dimethylbutanoic Acid → 2-tert-butyl-N-[2-(1-adamantylthio)ethyl-]glycine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Bromo-3,3-dimethylbutanoic Acid | HCID 184251 | — |
| 反応物 | 2-(Adamantan-1-ylthio)ethanamine | HCID 303799 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 溶媒 | tert-Butanol | HCID 6386 | — |
| 生成物 | 2-tert-butyl-N-[2-(1-adamantylthio)ethyl-]glycine | HCID 21439033 | — |
反応手順
A mixture of 42.3 parts of 2-(1-adamantylthio)ethylamine, 10.8 parts of sodium methoxide, 39.0 parts of 2-bromo-2-tert-butyl acetic acid and 315 parts of tert-butanol is refluxed, under a nitrogen atmosphere, for 5 hours. The product is recovered in the manner described in Example 5 to yield 2-tert-butyl-N-[2-(1 -adamantylthio)ethyl-]glycine, melting at about 220°-230°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04020079 |
| 出典データセット | uspto-grants-1977_04 |
| ORD ID | ord-49abff0ab6134960a4a17e04072b4618 |
| 出典メモ | uspto-grants-1977_04 |