Chloroethane → Diethyl acetylphosphonate

HRID 329221

反応式

HRID 329221 の反応式
[P:1]([O:8][CH2:9][CH3:10])([O:5][CH2:6][CH3:7])[O:2]CC.[C:11](Cl)(=[O:13])[CH3:12].C(Cl)C>>[C:11]([P:1](=[O:2])([O:5][CH2:6][CH3:7])[O:8][CH2:9][CH3:10])(=[O:13])[CH3:12]

参加物

4

反応物 3

HCID 6337Chloroethane2 回HCID 6367Acetyl chlorideHCID 31215Triethyl phosphite

生成物 1

HCID 522997Diethyl acetylphosphonate収率 98%

実験手順

166.2 grams (1 mole) triethyl phosphite was added dropwise with stirring to 78.4 grams (1 mole) of acetyl chloride over a period of 30 minutes at a temperature of 30° to 35° C maintained by cooling. Ethyl chloride was evolved. The temperature was increased to 60° C over the next 1 hour and 15 minutes, at which time the evolution of ethyl chloride was complete. The product was distilled under vacuum yielding 176 grams of diethyl acetylphosphonate (DEAP) in 98% yield, B.P. about 80° C at 5 mm and having a refractive index of 1.4240 at 200° C.

後処理

  1. temperaturemaintained
  2. temperatureby cooling
  3. distillationThe product was distilled under vacuum

出典と根拠

ORDレコード
ord-2dd7db1a4f0143b89435b1782c08c5c9
出典データセット
uspto-grants-1977_04
特許番号
US04020091

関連ノート

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