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Ammonia → 2,6-Dimethoxymethyl-4-(4'-methylmercaptophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 4-(Methylthio)benzaldehyde | HCID 76985 | — |
| 反応物 | Ethyl 4-methoxy-3-oxobutanoate | HCID 12645099 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2,6-Dimethoxymethyl-4-(4'-methylmercaptophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester | HCID 68121248 | 50% |
反応手順
7.6 g of 4-methylmercaptobenzaldehyde, 16 g of γ-methoxyacetoacetic acid ethyl ester and 6 ml of aqueous concentrated ammonia in 30 ml of ethanol are heated to the boil for 6-8 hours, and 2,6-dimethoxymethyl-4-(4'-methylmercaptophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester is obtained in the form of beige crystals of melting point 136°-138° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04020178 |
| 出典データセット | uspto-grants-1977_04 |
| ORD ID | ord-73b84b635c304d208b0b8b973465f8bb |
| 出典メモ | uspto-grants-1977_04 |