Ethyl 3-oxovalerate → Diethyl 2-Propionylazelate

HRID 329287ノート

反応式

HRID 329287 の反応式
[C:1]([CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7])(=[O:4])[CH2:2][CH3:3].[CH2:11]([O:13][C:14]([CH:16](C(=O)C)[CH2:17][C:18]#[C:19][CH2:20][CH2:21]CC(OC)=O)=[O:15])[CH3:12].BrCCCCCCC(OCC)=O>>[C:1]([CH:5]([CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][C:14]([O:13][CH2:11][CH3:12])=[O:15])[C:6]([O:8][CH2:9][CH3:10])=[O:7])(=[O:4])[CH2:2][CH3:3]

参加物

4

反応物 3

HCID 78656Ethyl 3-oxovalerateHCID 122490Ethyl 7-bromoheptanoateHCID 22759276Methyl 8-Ethoxycarbonyl-9-oxo-5-decynoate2 回

生成物 1

HCID 22759291Diethyl 2-Propionylazelate

実験手順

The synthesis of this compound is carried out by the procedure of Example 4, Step A, except that an equivalent quantity of ethyl propionylacetate is substituted for the ethyl acetoacetate of Example 4, Step A, and an equivalent quantity of ethyl 7-bromoheptanoate is substituted for the methyl 7-bromo-5-heptynoate of Example 4, Step A. The product, a viscous oil, is used in the next step directly without distillation.

後処理

  1. customThe synthesis of this compound
  2. distillationThe product, a viscous oil, is used in the next step directly without distillation

出典と根拠

ORDレコード
ord-1d04c4f7b26c455ab875a2cad5831cf3
出典データセット
uspto-grants-1977_04
特許番号
US04020177

反応ノート

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