化工社化工社 化学情報印刷レポート · 研究参考用
Dicyclohexylcarbodiimide → N,N'-Dicyclohexylurea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | Phenol, 4-(5-decyl-2-pyrimidinyl)- | HCID 135585902 | — |
| 反応物 | HCID 178444557 | HCID 178444557 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N,N'-Dicyclohexylurea | HCID 4277 | — |
反応手順
A solution of 35.4 g of 4-(5-decylpyrimidin-2-yl)phenol, 22.5 g of trans-4-pentylcyclohexanecarboxylic acid and 23.4 g of N,N'-dicyclohexylcarbodiimide in 600 ml of dichloromethane is stirred at 20° C. for 12 hours. The N,N'-dicyclohexylurea formed is filtered off, and the filtrate is chromatographed over 5 kg of silica gel using dichloromethane. The product-containing fraction gives 21.5 g of colorless crystals after recrystallization from n-hexane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04891151 |
| 出典データセット | uspto-grants-1990_01 |
| ORD ID | ord-52fde18c50ee408583b6415095779c69 |
| 出典メモ | uspto-grants-1990_01 |