N-[2-Iodo-4-nitro-5-(trifluoromethyl)phenyl]methanesulfonamide → 2-(1-methanesulfonyl-5-nitro-6-trifluoromethyl-1H-indol-2-yl)-1-(2,2,2-trifluoro-ethylsulfanyl)-butan-2-ol
反応式
I[C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[C:5]([C:11]([F:14])([F:13])[F:12])=[CH:4][C:3]=1[NH:15][S:16]([CH3:19])(=[O:18])=[O:17].[F:20][C:21]([F:32])([F:31])[CH2:22][S:23][CH2:24][C:25]([OH:30])([CH2:28][CH3:29])[C:26]#[CH:27]>>[CH3:19][S:16]([N:15]1[C:3]2[C:2](=[CH:7][C:6]([N+:8]([O-:10])=[O:9])=[C:5]([C:11]([F:14])([F:13])[F:12])[CH:4]=2)[CH:27]=[C:26]1[C:25]([OH:30])([CH2:28][CH3:29])[CH2:24][S:23][CH2:22][C:21]([F:20])([F:32])[F:31])(=[O:18])=[O:17]参加物
3
実験手順
This compound was prepared using the general Sonagashira procedure as described in General Procedures Example C, reacting N-(2-iodo-4-nitro-5- trifluoromethyl-phenyl) -methanesulfonamide (0.62 g, 1.5 mmol) and 3-(2,2,2-Trifluoro-ethylsulfanylmethyl) -pent-1yn-3-ol (0.32 g, 1.5 mmol) to yield the title compound as a yellow sticky oil.
後処理
- customThis compound was prepared
出典と根拠
- ORDレコード
- ord-193630d568814e61aeee6716b3ec60f1
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07427682B2
反応ノート
読み込み中…