2-Bromo-1-[3,5-di(tert-butyl)-4-hydroxyphenyl]ethan-1-one → 2H-Imidazo(2,1-b)(1,3,4)thiadiazin-6(7H)-one, 3-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)-, hydrobromide

HRID 329386

反応式

HRID 329386 の反応式
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[C:8]([OH:15])=[C:7]([C:16]([CH3:19])([CH3:18])[CH3:17])[CH:6]=1)=O.[NH2:20][N:21]1[C:25](=[O:26])[CH2:24][NH:23][C:22]1=[S:27]>>[BrH:1].[C:11]([C:9]1[CH:10]=[C:5]([C:3]2[CH2:2][S:27][C:22]3=[N:23][CH2:24][C:25](=[O:26])[N:21]3[N:20]=2)[CH:6]=[C:7]([C:16]([CH3:19])([CH3:18])[CH3:17])[C:8]=1[OH:15])([CH3:14])([CH3:13])[CH3:12]

参加物

3

反応物 2

HCID 6161612-Bromo-1-[3,5-di(tert-butyl)-4-hydroxyphenyl]ethan-1-oneHCID 142110443-Amino-2-sulfanylideneimidazolidin-4-one

生成物 1

HCID 30883862H-Imidazo(2,1-b)(1,3,4)thiadiazin-6(7H)-one, 3-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)-, hydrobromide

実験手順

34.4 g (0.11 mol) of 2-bromo-1-(3,5-di-tert.butyl-4-hydroxyphenyl)-ethanone from Example 1(a) and 13.8 g (0.11 mol) of 1-amino-2-thioxo-5-imidazolidinone from step (a) were heated at 90° C. for 30 minutes in 300 ml of glacial acelic acid. After cooling, the precipitate was filtered off and washed with 250 ml of ethyl acetate, and the crystals were dried in vacuo over phosphorus pentoxide.

後処理

  1. temperatureAfter cooling
  2. filtrationthe precipitate was filtered off
  3. washwashed with 250 ml of ethyl acetate
  4. dry with materialthe crystals were dried in vacuo over phosphorus pentoxide

出典と根拠

ORDレコード
ord-54c15c30e1fa4ef3b2056b4250981e34
出典データセット
uspto-grants-1990_01
特許番号
US04891374

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