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(S)-2-Amino-2,3-dimethylbutanamide → 5-Acetoxy-2-(1-carbamoyl-1,2-dimethylpropyl-carbamoyl)-6-methyl-nicotinic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (S)-2-Amino-2,3-dimethylbutanamide | HCID 10154071 | — |
| 反応物 | 5-Acetoxy-6-methyl-pyridine-2,3-dicarboxylic acid anhydride | HCID 13799444 | — |
| 生成物 | 5-Acetoxy-2-(1-carbamoyl-1,2-dimethylpropyl-carbamoyl)-6-methyl-nicotinic acid | HCID 13799445 | — |
反応手順
6.3 g (28.48 mmol) 5-acetoxy-6-methyl-pyridine-2,3-dicarboxylic acid anhydride and 4.1 g (31.33 mmol) 2-methyl-valinamide are stirred under nitrogen for 2 days at room temperature, and then the precipitated crystalline product is filtered off.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04891428 |
| 出典データセット | uspto-grants-1990_01 |
| ORD ID | ord-2dd1b797f7c845f08bd0654c2c56b35f |
| 出典メモ | uspto-grants-1990_01 |