Dicyclohexylcarbodiimide → HCID 15052024、化合物

HRID 329568ノート

反応式

HRID 329568 の反応式
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][C:11]([NH:13][C:14]1[CH:19]=[CH:18][C:17]([CH2:20][N:21]2[C:25](=[O:26])[C:24]([CH3:28])([CH3:27])[CH2:23][O:22]2)=[CH:16][CH:15]=1)=O)([OH:3])=[O:2].C1(N=C=NC2CCCCC2)CCCCC1>C1(C)C=CC=CC=1>[C:1]1(=[O:3])[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[CH:10]=[C:11]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][N:21]3[C:25](=[O:26])[C:24]([CH3:27])([CH3:28])[CH2:23][O:22]3)=[CH:16][CH:15]=2)[O:2]1

参加物

4

反応物 2

HCID 10868DicyclohexylcarbodiimideHCID 15052016HCID 15052016、化合物

生成物 1

HCID 15052024HCID 15052024、化合物収率 109.8%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of 0.57 gram (0.0015 mole) of 2-[[4-[(2-carboxyphenylmethyl)carbonylamino]phenyl]methyl]-4,4-dimethyl-3-isoxazolidinone in 100 mL of toluene was cooled in an ice bath, and, with stirring, 0.33 gram (0.0016 mole) of dicyclohexylcarbodiimide was added in one portion. Upon completion of addition the reaction mixture was allowed to warm to ambient temperature where it was stirred for 16 hours. The resultant solid was collected by filtration to yield 0.60 gram of 2-[[4-[(1H-2-benzopyran-1-one-3-yl)amino]phenyl]methyl]-4,4-dimethyl-3-isoxazolidinone; m.p. 175°-177° C.

後処理

  1. additionUpon completion of addition the reaction mixture
  2. stirringwas stirred for 16 hours
  3. filtrationThe resultant solid was collected by filtration

出典と根拠

ORDレコード
ord-ec648fc7aae44292a197c6bb9386d8b1
出典データセット
uspto-grants-1990_01
特許番号
US04892578

反応ノート

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