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2-Hydroxy-1-naphthaldehyde → 2-(5-carboxy-2-benzoxazolyl)-3H-naphtho[2,1-b]pyran-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Hydroxy-1-naphthaldehyde | HCID 12819 | — |
| 反応物 | 2-Ethoxycarbonylmethyl-5-carboxybenzoxazole | HCID 19871424 | — |
| 触媒 | Acetic Acid | HCID 176 | — |
| 触媒 | Piperidine | HCID 8082 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-(5-carboxy-2-benzoxazolyl)-3H-naphtho[2,1-b]pyran-3-one | HCID 19871423 | 56% |
反応手順
A mixture of 2-hydroxy-1-naphthaldehyde (1.72 g, 0.01 mol), 2-ethoxycarbonylmethyl-5-carboxybenzoxazole (2.49 g, 0.01 mol), ethanol (30 mL), piperidine (10 drops), and acetic acid (5 drops) is heated at reflux for 3 hours. After cooling the reaction mixture is filtered to isolate the yellow fluorescent product which is then washed with ethanol and dried in air to yield 2.0 g (56% of theory) of 2-(5-carboxy-2-benzoxazolyl)-3H-naphtho[2,1-b]pyran-3-one having the structure ##STR19##
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04892923 |
| 出典データセット | uspto-grants-1990_01 |
| ORD ID | ord-f256b0f0768d4dde922bb36ecab302f2 |
| 出典メモ | uspto-grants-1990_01 |