Hydrochloric Acid → 2-Hydroxy-3,5-dimethyl-2-cyclopenten-1-one

HRID 329809ノート

反応式

HRID 329809 の反応式
C[O:2][C:3]1[C:4](=[O:10])[CH:5]([CH3:9])[CH2:6][C:7]=1[CH3:8].Cl>>[OH:10][C:4]1[C:3](=[O:2])[CH:7]([CH3:8])[CH2:6][C:5]=1[CH3:9]

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 1121722-Cyclopenten-1-one, 2-methoxy-3,5-dimethyl-

生成物 1

HCID 895382-Hydroxy-3,5-dimethyl-2-cyclopenten-1-one収率 54.2%

実験手順

2.15 g (15.36 mmol) of crude 2-methoxy-3,5-dimethyl-2-cyclopenten-1-one are held at reflux temperature for 2 hours with 21.50 g (=10 fold amount by weight) of 5N hydrochloric acid. The reaction mixture is extracted 3 times with 50 ml of CH2Cl2 each time. The combined organic phases are dried over magnesium sulphate and concentrated on a rotary evaporator. After recrystallization from ether/hexane 1:1 there are obtained 1.05 g (54.2%) 2-hydroxy-3,5-dimethyl-2-cyclopenten-1-one; m.p. 92°-93° C.

後処理

  1. extractionThe reaction mixture is extracted 3 times with 50 ml of CH2Cl2 each time
  2. dry with materialThe combined organic phases are dried over magnesium sulphate
  3. concentrationconcentrated on a rotary evaporator
  4. customAfter recrystallization from ether/hexane 1:1 there

出典と根拠

ORDレコード
ord-63a0285508a44711b0ed50e52b2a6e79
出典データセット
uspto-grants-1990_01
特許番号
US04892966

反応ノート

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