Hydrochloric Acid → 2-(4-Benzhydryl-1-piperazinyl)ethyl methyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride

HRID 329880ノート

反応式

HRID 329880 の反応式
[N:1]1[O:2][N:3]=[C:4]2[C:9]([CH:10]=O)=[CH:8][CH:7]=[CH:6][C:5]=12.[C:12]([O:18][CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][N:24]([CH:27]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH2:23][CH2:22]1)(=[O:17])[CH2:13][C:14]([CH3:16])=O.[NH2:40]/[C:41](/[CH3:47])=[CH:42]\[C:43]([O:45][CH3:46])=[O:44].[ClH:48]>C(O)(C)C>[ClH:48].[ClH:48].[N:1]1[O:2][N:3]=[C:4]2[C:9]([CH:10]3[C:42]([C:43]([O:45][CH3:46])=[O:44])=[C:41]([CH3:47])[NH:40][C:14]([CH3:16])=[C:13]3[C:12]([O:18][CH2:19][CH2:20][N:21]3[CH2:26][CH2:25][N:24]([CH:27]([C:28]4[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=4)[C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)[CH2:23][CH2:22]3)=[O:17])=[CH:8][CH:7]=[CH:6][C:5]=12

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 643918Methyl 3-aminocrotonateHCID 102908732,1,3-Benzoxadiazole-4-carbaldehydeHCID 11740518Butanoic acid, 3-oxo-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ester

生成物 1

HCID 198712592-(4-Benzhydryl-1-piperazinyl)ethyl methyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride収率 45%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

A mixture of 2,1,3-benzoxadiazole-4-carbaldehyde, 2-(4-benzhydryl-1-piperazinyl)ethyl acetoacetate and methyl 3-aminocrotonate was worked up in isopropyl alcohol in the same manner as Example 1 and the product obtained was further treated with methanolic hydrogen chloride solution to give 2-(4-benzhydryl-1-piperazinyl)ethyl methyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride as light yellow crystals, m.p. 192°-198° C. Yield 45.0%.

後処理

  1. customthe product obtained

出典と根拠

ORDレコード
ord-04b4bc05d1684e898c30c0fa33f2650e
出典データセット
uspto-grants-1990_01
特許番号
US04892875

反応ノート

読み込み中…