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Diazomethane → 2-(4-Chlorobenzoyl)-2-(4-chlorophenyl)oxirane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diazomethane | HCID 9550 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 1,2-Ethanedione, 1,2-bis(4-chlorophenyl)- | HCID 18946 | — |
| 反応物 | Urea, (nitrosomethyl)- | HCID 104823 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 2-(4-Chlorobenzoyl)-2-(4-chlorophenyl)oxirane | HCID 19870084 | — |
反応手順
With cooling and stirring, an ethereal diazomethane solution prepared by reaction of 5.34 g of N-nitrosomethylurea with aqueous sodium hydroxide solution in ether is added dropwise to a solution of 5 g of 4,4'-dichlorobenzil in 50 ml of dioxane. When the dropwise addition is complete, stirring is continued for 16 hours at room temperature, and the reaction solution is then concentrated by evaporation. The residual oil is crude 2-(4-chlorobenzoyl)-2-(4-chlorophenyl)oxirane which is purified by high vacuum distillation.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04894083 |
| 出典データセット | uspto-grants-1990_01 |
| ORD ID | ord-057994b302f2495bbcf07f493a65ad1e |
| 出典メモ | uspto-grants-1990_01 |