Sulfuric Acid → 2,4,5-Trifluoro-3-methylbenzamide
反応式
[F:1][C:2]1[C:9]([CH3:10])=[C:8]([F:11])[C:7]([F:12])=[CH:6][C:3]=1[C:4]#[N:5].S(=O)(=O)(O)[OH:14]>>[F:1][C:2]1[C:9]([CH3:10])=[C:8]([F:11])[C:7]([F:12])=[CH:6][C:3]=1[C:4]([NH2:5])=[O:14]参加物
3
実験手順
A mixture of 2,4,5-trifluoro-3-methylbenzonitrile (0.50 g) in concentrated sulfuric acid (0.3 ml) was stirred on an oil bath (90° to 100° C.) for 1 hour. After cooling, to the reacting mixture was added ice-water (5 ml), the resulting precipitate was collected by filtration, washed with water sufficiently and dried to give the title compound (0.52 g), mp 105°-108° C. This crystals were recrystallized from hexane to give colorless crystals, mp 112°-113° C.
後処理
- temperatureAfter cooling, to the reacting mixture
- filtrationthe resulting precipitate was collected by filtration
- washwashed with water sufficiently
- customdried
出典と根拠
- ORDレコード
- ord-f228c8d379e24cb1a2230d2cb5f80d1e
- 出典データセット
- uspto-grants-1990_01
- 特許番号
- US04894458
反応ノート
読み込み中…