Sulfuric Acid → 2,4,5-Trifluoro-3-methylbenzoic acid
反応式
[F:1][C:2]1[C:10]([CH3:11])=[C:9]([F:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4](N)=[O:5].S(=O)(=O)(O)[OH:15]>>[F:1][C:2]1[C:10]([CH3:11])=[C:9]([F:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4]([OH:15])=[O:5]参加物
3
実験手順
A mixture of 2,4,5-trifluoro-3-methylbenzamide (0.38 g) in 18N sulfuric acid (3 ml) was stirred on an oil bath (100° to 110° C.) for 2 hours. After cooling, to the reacting mixture was added ice-water (10 ml), the resulting precipitate was collected by filtration and recrystallized from hexane to give the title compound (0.30 g) as colorless needles, mp 103°-105° C.
後処理
- temperatureAfter cooling, to the reacting mixture
- filtrationthe resulting precipitate was collected by filtration
- customrecrystallized from hexane
出典と根拠
- ORDレコード
- ord-0dd6b1790df548e48c011753de84ba03
- 出典データセット
- uspto-grants-1990_01
- 特許番号
- US04894458
反応ノート
読み込み中…