Acetic Anhydride → HCID 53656353、化合物

反応式

[F:1][C:2]1[C:15]([CH3:16])=[C:14]([F:17])[C:13]([F:18])=[CH:12][C:3]=1[C:4]([CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].[CH:19]([O-])([O-])[O:20][CH2:21][CH3:22].C(OC(=O)C)(=O)C>>[F:1][C:2]1[C:15]([CH3:16])=[C:14]([F:17])[C:13]([F:18])=[CH:12][C:3]=1[C:4]([C:6](=[CH:19][O:20][CH2:21][CH3:22])[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5]

参加物

反応物 3

HCID 7918Acetic Anhydride

HCID 14052572Ethyl 3-oxo-3-(2,4,5-trifluoro-3-methylphenyl)propanoate

HCID 53630039Ethylorthoformate

生成物 1

HCID 53656353HCID 53656353、化合物収率 99.2%

実験手順

A mixture of ethyl 2-(2,4,5-trifluoro-3-methylbenzoyl)acetate (5.02 g), ethyl orthoformate (4.29 g) and acetic anhydride (4.93 g) was stirred at 130° to 135° C. for 5 hours and then concentrated under reduced pressure to give the title compound (6.05 g) as red oil.