Ammonium Chloride → 7-(2-Hexyl-5-keto-cyclopentyl)-heptanoic acid, methyl ester

反応式

[O:1]=[C:2]1[C:6]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([O:15][CH3:16])=[O:14])=[CH:5][CH2:4][CH2:3]1.[Cl-].[NH4+]>>[CH2:7]([CH:5]1[CH2:4][CH2:3][C:2](=[O:1])[CH:6]1[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([O:15][CH3:16])=[O:14])[CH2:6][CH2:2][CH2:3][CH2:4][CH3:5]

参加物

反応物 2

HCID 25517Ammonium Chloride

HCID 2777884Methyl 5-oxocyclopent-1-ene-1-heptanoate

生成物 1

HCID 214205217-(2-Hexyl-5-keto-cyclopentyl)-heptanoic acid, methyl ester

反応条件

温度: -20 °C

実験手順

The mixture is cooled to -20° C. and the methyl ester (VII) (30 g; 0.134 mole) is added dropwise, at the end of which a saturated ammonium chloride solution is added slowly. The phases are separated, the organic phase is washed to neutrality yielding a pale yellow oil (40.7 g; yield=98%).

後処理

additionis added slowly
customThe phases are separated
washthe organic phase is washed
customto neutrality yielding a pale yellow oil (40.7 g; yield=98%)

出典と根拠

ORDレコード: ord-db0d25b1a59b4fcf91173aecff6f6c98
出典データセット: uspto-grants-1990_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04894473

反応ノート

読み込み中…

参加物